10 Best Immune System & Allergy Supplements for Dogs 2025: According to Reviews | Chewy

The 10 Best Immune System & Allergy Supplements for Dogs

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How we created this immune system & allergy supplement list

We leveraged input from our veterinarians and artificial intelligence to identify key considerations to help you find the best immune system & allergy supplements for dog.
We scanned thousands of customer reviews and ratings and scored each product based on its performance against each of the key considerations. We then considered how popular a product is with Chewy customers and combined that with its key consideration scores to create the list of the best immune system & allergy supplements for dogs.

Key immune system & allergy supplement considerations

Dosage and Administration

Effectiveness

Ingredients

Safety

1
Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz
Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz
Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz
Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz
Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz
Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz
Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz

Native Pet Colostrum Immune System Powder Supplement for Dogs, 2.2-oz

Rated 4.7 out of 5 stars
271
$29.99Chewy Price
($13.64/oz)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.7/5
Excellent

Effectiveness

4.8/5
Excellent

Ingredients

4.8/5
Excellent

Safety

4.8/5
Excellent

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages

Special Diet

Gluten Free, No Corn No Wheat No Soy

Packaging Type

Can, Bag
2
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count
Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count

Pupford Gut Health & Immunity Peanut Butter & Jelly Flavored Soft Chew Digestive Support Supplement for Puppies, 60 count

Rated 4.8 out of 5 stars
143
$21.99Chewy Price
($0.37/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.8/5
Excellent

Effectiveness

4.9/5
Excellent

Ingredients

4.8/5
Excellent

Safety

4.8/5
Excellent

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

Puppy

Top Ingredients

Pumpkin Powder, Chicory Root, Yea-Sacc OA, Tynagen, 7-strain Immunity Blend

Special Diet

Natural, No Corn No Wheat No Soy, Low Fat, Limited Ingredient Diet...
3
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count
Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count

Zesty Paws Allergy & Immune Bites Lamb Flavored Soft Chews Allergies, Immune, & Gut Support Supplement for Dogs, 90 count

Rated 4.4 out of 5 stars
5,077
$26.49Chewy Price
($0.30/ea)
Promo, Save 50% on your first Autoship

Our ratings

Dosage and Administration

3.8/5
Good

Effectiveness

3.8/5
Good

Ingredients

3.9/5
Good

Safety

3.8/5
Good

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Colostrum (Bovine) 200 mg, Dried Fermentate (Made Using Saccharomyces cerevisiae) (EpiCor Pets) 170 mg, Astragalus Root 100 mg, 6-Strain Gut Health Blend (Bacillus subtilis, Lactobacillus acidophilus

Food Flavor

Lamb, Meat
4
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count
Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count

Vibeful Allergy & Immune Support Peanut Butter Flavored Soft Chews Allergy & Immune Supplement for Dogs, 90-Count

Rated 4.1 out of 5 stars
831
$19.99Chewy Price
($0.23/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.1/5
Great

Effectiveness

4.1/5
Great

Ingredients

4.2/5
Great

Safety

4.0/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Colostrum, Apple Cider Vinegar, Salmon Oil, Astragalus Root, Wellmune® Baker’s Yeast Beta 1

Food Flavor

Peanut Butter
5
VetriScience Vetri-DMG Liquid Immune Supplement for Dogs, Cats & Birds, 114-mL
VetriScience Vetri-DMG Liquid Immune Supplement for Dogs, Cats & Birds, 114-mL
VetriScience Vetri-DMG Liquid Immune Supplement for Dogs, Cats & Birds, 114-mL
VetriScience Vetri-DMG Liquid Immune Supplement for Dogs, Cats & Birds, 114-mL
VetriScience Vetri-DMG Liquid Immune Supplement for Dogs, Cats & Birds, 114-mL
VetriScience Vetri-DMG Liquid Immune Supplement for Dogs, Cats & Birds, 114-mL

VetriScience Vetri-DMG Liquid Immune Supplement for Dogs, Cats & Birds, 114-mL

Rated 4.6 out of 5 stars
240
$27.49Chewy Price
($0.25/mL)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.6/5
Excellent

Effectiveness

4.6/5
Excellent

Ingredients

4.6/5
Excellent

Safety

4.4/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Each Drop Contains: 6 mg, of N-Dimethylglycine (D mg )., Inactive Ingredients: Citric Acid, Glycerin, Malic Acid

Special Diet

Human-Grade
6
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count
StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count

StrellaLab Probiotics & Digestive Enzymes Fiber & Digestion & Gut Health Chew Supplement for Dogs, 120 count

Rated 4.5 out of 5 stars
228
$19.98Chewy Price
($0.17/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.5/5
Great

Effectiveness

4.4/5
Great

Ingredients

4.4/5
Great

Safety

4.2/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Brewers Dried Yeast, Dried Potato Product, Glycerin, Flaxseed, Lecithin

Special Diet

Rawhide-Free, No Corn No Wheat No Soy
7
Pet Honesty Allergy Support Salmon Flavored Colostrum & Turmeric Chews, Itchy Skin, Immune & Allergy Relief Supplement for Dogs, 90 count
Pet Honesty Allergy Support Salmon Flavored Colostrum & Turmeric Chews, Itchy Skin, Immune & Allergy Relief Supplement for Dogs, 90 count
Pet Honesty Allergy Support Salmon Flavored Colostrum & Turmeric Chews, Itchy Skin, Immune & Allergy Relief Supplement for Dogs, 90 count
Pet Honesty Allergy Support Salmon Flavored Colostrum & Turmeric Chews, Itchy Skin, Immune & Allergy Relief Supplement for Dogs, 90 count
Pet Honesty Allergy Support Salmon Flavored Colostrum & Turmeric Chews, Itchy Skin, Immune & Allergy Relief Supplement for Dogs, 90 count
Pet Honesty Allergy Support Salmon Flavored Colostrum & Turmeric Chews, Itchy Skin, Immune & Allergy Relief Supplement for Dogs, 90 count
Pet Honesty Allergy Support Salmon Flavored Colostrum & Turmeric Chews, Itchy Skin, Immune & Allergy Relief Supplement for Dogs, 90 count
Pet Honesty Allergy Support Salmon Flavored Colostrum & Turmeric Chews, Itchy Skin, Immune & Allergy Relief Supplement for Dogs, 90 count
Pet Honesty Allergy Support Salmon Flavored Colostrum & Turmeric Chews, Itchy Skin, Immune & Allergy Relief Supplement for Dogs, 90 count

Pet Honesty Allergy Support Salmon Flavored Colostrum & Turmeric Chews, Itchy Skin, Immune & Allergy Relief Supplement for Dogs, 90 count

Rated 4.2 out of 5 stars
5,491
$32.99Chewy Price
($0.37/ea)
Promo, Save 50% on your first Autoship

Our ratings

Dosage and Administration

3.6/5
Good

Effectiveness

3.7/5
Good

Ingredients

3.6/5
Good

Safety

3.6/5
Good

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Colostrum, Organic Turmeric Root, Wild Alaskan Salmon Oil, Vitamin C, Organic Mushroom Blend

Special Diet

No Corn No Wheat No Soy, Non-GMO
8
VEDCO NutriVed Dietary Chewable Dog Supplement, 100 count
VEDCO NutriVed Dietary Chewable Dog Supplement, 100 count
VEDCO NutriVed Dietary Chewable Dog Supplement, 100 count

VEDCO NutriVed Dietary Chewable Dog Supplement, 100 count

Rated 4.3 out of 5 stars
134
$15.98Chewy Price
($0.16/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.6/5
Excellent

Effectiveness

4.7/5
Excellent

Ingredients

4.5/5
Great

Safety

4.4/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Zinc Methionine, Liver Meal, Roast Beef Flavor, Dried Whey, Calcium Carbonate

Food Flavor

Beef, Liver, Meat
9
NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count
NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count
NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count
NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count
NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count
NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count
NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count

NaturVet Mushroom Max Immunity Hickory Smoked Bacon Flavored Supplement for Dogs & Cats, 120 count

Rated 4.4 out of 5 stars
281
$42.97Chewy Price
($0.36/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.2/5
Great

Effectiveness

4.2/5
Great

Ingredients

4.1/5
Great

Safety

4.1/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Lifestage

All Lifestages, Adult

Top Ingredients

Active Ingredients: Reishi Mushroom, Shiitake Mushroom, Turkey Tail Mushroom, Maitake Mushroom, N-acetyl-L-cysteine

Food Flavor

Turkey, Poultry
10
Native Pet Allergy & Immune Chews Allergy Relief Supplement for Dogs, 60 count
Native Pet Allergy & Immune Chews Allergy Relief Supplement for Dogs, 60 count
Native Pet Allergy & Immune Chews Allergy Relief Supplement for Dogs, 60 count
Native Pet Allergy & Immune Chews Allergy Relief Supplement for Dogs, 60 count
Native Pet Allergy & Immune Chews Allergy Relief Supplement for Dogs, 60 count
Native Pet Allergy & Immune Chews Allergy Relief Supplement for Dogs, 60 count
Native Pet Allergy & Immune Chews Allergy Relief Supplement for Dogs, 60 count

Native Pet Allergy & Immune Chews Allergy Relief Supplement for Dogs, 60 count

Rated 4.2 out of 5 stars
717
$24.98Chewy Price
($0.42/ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card

Our ratings

Dosage and Administration

4.0/5
Great

Effectiveness

4.1/5
Great

Ingredients

4.1/5
Great

Safety

4.0/5
Great

Is this immune system & allergy supplement right for my pet?

Breed Size

All Breeds

Top Ingredients

Active Ingredients: Colustrum, Spirulina, Colostrum, Dried Yeast Fermentate, Algae Oil

Special Diet

Gluten Free, Natural, Limited Ingredient Diet, Grain-Free

Food Flavor

Chicken